This gene encodes the third discovered human homologue ofthe Drosophilia melanogaster type I membrane protein notch. InDrosophilia, notch interaction with its cell-bound ligands (delta,serrate) establishes an intercellular signalling pathway that playsa key role in neural development. Homologues of the notch-ligandshave also been identified in human, but precise interactionsbetween these ligands and the human notch homologues remains to bedetermined. Mutations in NOTCH3 have been identified as theunderlying cause of cerebral autosomal dominant arteriopathy withsubcortical infarcts and leukoencephalopathy (CADASIL). [providedby RefSeq].

Titration of the NOTCH3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 2291-2321 from the human protein was used as the immunogen for this NOTCH3 antibody.

Aliquot the NOTCH3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.