Voltage-gated proton (hydrogen) channels play an importantrole in cellular defense against acidic stress. They are uniqueamong ion channels with respect to their extremely highselectivity, marked temperature dependence, and unitaryconductance, which is 3 orders of magnitude lower than that of mostother ion channels. NOX1 is a homolog of the catalytic subunit ofthe superoxide-generating NADPH oxidase of phagocytes, gp91phox.Two transcript variants encoding different isoforms have been foundfor this gene.
Titration of the NOX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 243-271 from the human protein was used as the immunogen for this NOX1 antibody.
Aliquot the NOX1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
