This gene encodes a protein that homodimerizes andfunctions as a transcription factor which activates the expressionof some key metabolic genes regulating cellular growth and nucleargenes required for respiration, heme biosynthesis, andmitochondrial DNA transcription and replication. The protein hasalso been associated with the regulation of neurite outgrowth.Alternate transcriptional splice variants, which encode the sameprotein, have been characterized. Additional variants encodingdifferent protein isoforms have been described but they have notbeen fully characterized. Confusion has occurred in bibliographicdatabases due to the shared symbol of NRF1 for this gene and for"nuclear factor (erythroid-derived 2)-like 1" which has an officialsymbol of NFE2L1.

Titration of the NRF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 226-255 from the human protein was used as the immunogen for this NRF1 antibody.

Aliquot the NRF1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.