This gene encodes a membrane glycoprotein of T lymphocytesthat interacts with major histocompatibility complex class IIantigenes and is also a receptor for the human immunodeficiencyvirus. This gene is expressed not only in T lymphocytes, but alsoin B cells, macrophages, and granulocytes. It is also expressed inspecific regions of the brain. The protein functions to initiate oraugment the early phase of T-cell activation, and may function asan important mediator of indirect neuronal damage in infectious andimmune-mediated diseases of the central nervous system. Multiplealternatively spliced transcript variants encoding differentisoforms have been identified in this gene.

Titration of the OKT4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This monoclonal OKT4 antibody was produced from a mouse immunized with human peripheral T cells.

Aliquot the OKT4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.