OTUD5 (ovarian tumor domain-containing 5), also called DUBA (Deubiquitinating enzyme A), is a product of the OTUD5 gene, and a suppressor of the innate immune response via its deubiquitinating activity.The Innate immune systems provide immediate but short-lived defense against infection identified by PRRs, or pattern recognition receptors.OTUD5 cleaves the lysine-63-linked polyubiquitin chains of TRAF3, causing it to dissociate from TBK1, thereby failing to stimulate IFN type 1 production and leading to a suppressed innate immune response.

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

A recombinant protein fragment from the C-terminal region of human OTUD5 was used as the immunogen for this antibody.

Aliquot the antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.

DUBA, Deubiquitinating enzyme A, OTU domain containing protein 5