Protein kinase C and casein kinase substrate in neurons protein 2 is a lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle- mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

Titration of the PACSIN2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A partial recombinant protein corresponding to amino acids 250-486 from the human protein was used as the immunogen for the PACSIN2 antibody.

Aliquot the PACSIN2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.