PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3, PAK4, PAK5, and PAK6. PAK proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton.

Titration of the PAK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 156-187 from the human protein was used as the immunogen for this PAK4 antibody.

Aliquot the PAK4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.