This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase"s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3"-5" exonuclease and 3"-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2.

Titration of the PCNA antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 236-261 from human Proliferating Cell Nuclear Antigen was used as the immunogen for this PCNA antibody.

Aliquot the PCNA antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.