Proprotein convertases, including PCSK4, arecalcium-dependent serine proteases related to bacterial subtilisinsand to yeast kexin. These enzymes process precursor proteins totheir active forms by selective cleavage of the polypeptide atsites following paired basic amino acids. In mammals, this familycomprises PC1 (MIM 162150), PC2 (MIM 162151), PC4, PC5 (MIM600488), furin (FUR; MIM 136950), and PACE4 (MIM 167405).Substrates for these enzymes range from prohormones to precursorsfor growth factors to cell surface receptors and viral surfaceglycoproteins (Cao et al., 2001 [PubMed 11776387]).[supplied byOMIM].

Titration of the PCSK4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 168-196 from the human protein was used as the immunogen for this PCSK4 antibody.

Aliquot the PCSK4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.