The protein encoded by this gene belongs to thesubtilisin-like proprotein convertase family. The members of thisfamily are proprotein convertases that process latent precursorproteins into their biologically active products. This encodedprotein is a calcium-dependent serine endoprotease that can cleaveprecursor protein at their paired basic amino acid processingsites. Some of its substrates are - transforming growth factor betarelated proteins, proalbumin, and von Willebrand factor. This geneis thought to play a role in tumor progression. Alternativelyspliced transcript variants encoding different isoforms have beenidentified.

Titration of the PCSK6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 659-688 from the human protein was used as the immunogen for this PCSK6 antibody.

Aliquot the PCSK6 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.