This gene encodes an integral outer mitochondrial membraneprotein that blocks the apoptotic death of some cells such aslymphocytes. Constitutive expression of BCL2, such as in the caseof translocation of BCL2 to Ig heavy chain locus, is thought to bethe cause of follicular lymphoma. Two transcript variants, producedby alternate splicing, differ in their C-terminal ends. [providedby RefSeq].

Titration of the phospho-Bcl-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This phospho-Bcl-2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS70 of human Bcl-2.

Aliquot the phospho-Bcl-2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.