This gene encodes a protein which is a member of thecysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phaseof cell apoptosis. Caspases exist as inactive proenzymes whichundergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form theactive enzyme. This protein cleaves and activates caspases 6, 7 and9, and the protein itself is processed by caspases 8, 9 and 10. Itis the predominant caspase involved in the cleavage of amyloid-beta4A precursor protein, which is associated with neuronal death inAlzheimer"s disease. Alternative splicing of this gene results intwo transcript variants that encode the same protein. [provided byRefSeq].

Titration of the phospho-Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This phospho-Caspase-3 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS26 of mouse CASP3.

Aliquot the phospho-Caspase-3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.