This intronless gene encodes a member of the SRY-relatedHMG-box (SOX) family of transcription factors involved in theregulation of embryonic development and in the determination ofcell fate. The product of this gene is required for stem-cellmaintenance in the central nervous system, and also regulates geneexpression in the stomach. Mutations in this gene have beenassociated with optic nerve hypoplasia and with syndromicmicrophthalmia, a severe form of structural eye malformation. Thisgene lies within an intron of another gene called SOX2 overlappingtranscript (SOX2OT).

Titration of the phospho-SOX2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This phospho-SOX2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS246 of human SOX2.

Aliquot the phospho-SOX2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.