The DNA-associated protein encoded by this gene is amember of the paired family of homeobox proteins localized to thenucleus. The protein functions as a transcription factor involvedin the development of several major noradrenergic neuronpopulations and the determination of neurotransmitter phenotype.The gene product is linked to enhancement of secondmessenger-mediated activation of the dopamine beta-hydroylase,c-fos promoters and several enhancers, including cyclicamp-response element and serum-response element. [provided byRefSeq].
Titration of the PHOX2B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 104-130 from the human protein was used as the immunogen for this PHOX2B antibody.
Aliquot the PHOX2B antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
