This gene encodes a member of the steroid receptorsuperfamily. The encoded protein mediates the physiological effectsof progesterone, which plays a central role in reproductive eventsassociated with the establishment and maintenance of pregnancy.This gene uses two distinct promotors and translation start sitesin the first exon to produce two isoforms, A and B. The twoisoforms are identical except for the additional 165 amino acidsfound in the N-terminus of isoform B and mediate their own responsegenes and physiologic effects with little overlap. The location oftranscription initiation for isoform A has not been clearlydetermined.

Titration of the Progesterone Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 523-550 from the human protein was used as the immunogen for this Progesterone Receptor antibody.

Aliquot the Progesterone Receptor antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.