F2 (Coagulation Factor II), also known as prothrombin and thrombin, is a serine protease that in humans is encoded by the F2 gene. The activated thrombin enzyme plays an important role in hemostasis and thrombosis: it converts fibrinogen to fibrin for blood clot formation, stimulates platelet aggregation, and activates coagulation factors V, VIII (F8), and XIII (F13A1). Thrombin also inhibits coagulation by Activating protein C.

Titration of the Prothrombin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Amino acids 600-612 (THVFRLKRWMQKV-rat) were used as the immunogen for this Prothrombin antibody.

After reconstitution, the Prothrombin antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.