The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the peptidase T1A family, that is a 20S core alphasubunit. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.
Titration of the PSMA1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 234-262 from the human protein was used as the immunogen for this PSMA1 antibody.
Aliquot the PSMA1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
