Protein tyrosine phosphatase, non-receptor type 22 (lymphoid), also known as PTPN22, is a protein that in humans is encoded by the PTPN22 gene. This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves" disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Optimal dilution of the Ptpn22 antibody should be determined by the researcher.

A recombinant mouse partial protein corresponding to amino acids M1-Q309 was used as the immunogen for the Ptpn22 antibody.

After reconstitution, the Ptpn22 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.