This gene is a member of the small GTPase superfamily andencodes a lipid-anchored, cell membrane protein with five repeatsof the RAS-related GTP-binding region. This protein is vital inregulation of growth and cell cycle progression due to its role inthe insulin/TOR/S6K signaling pathway. The protein has GTPaseactivity and shuttles between a GDP-bound form and a GTP-boundform, and farnesylation of the protein is required for thisactivity. Three pseudogenes have been mapped, two on chromosome 10and one on chromosome 22.

Titration of the RHEB antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 104-134 from the human protein was used as the immunogen for this RHEB antibody.

Aliquot the RHEB antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.