Retinitis pigmentosa is an inherited progressive diseasewhich is a major cause of blindness in western communities. It canbe inherited as an autosomal dominant, autosomal recessive, orX-linked recessive disorder. In the autosomal dominant form,whichcomprises about 25% of total cases, approximately 30% of familieshave mutations in the gene encoding the rod photoreceptor-specificprotein rhodopsin. This is the transmembrane protein which, whenphotoexcited, initiates the visual transduction cascade. Defects inthis gene are also one of the causes of congenital stationary nightblindness.

Titration of the RHO antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 310-339 from human Rhodopsin was used as the immunogen for this RHO antibody.

Aliquot the RHO antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.