Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 "Ser-473" phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on "Thr-308" by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at "Ser-422". mTORC2 also modulates the phosphorylation of PRKCA on "Ser-657". Plays an essential role in embryonic growth and development.

Titration of the RICTOR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This RICTOR antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 1068-1102 amino acids from the Central region of human RICTOR.

Aliquot the RICTOR antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.