The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.

Titration of the RNF40 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 697-725 from the human protein was used as the immunogen for this RNF40 antibody.

Aliquot the RNF40 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.