Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a cytoplasmicribosomal protein that is a component of the 40S subunit. Theprotein belongs to the S6E family of ribosomal proteins. It is themajor substrate of protein kinases in the ribosome, with subsets offive C-terminal serine residues phosphorylated by different proteinkinases. Phosphorylation is induced by a wide range of stimuli,including growth factors, tumor-promoting agents, and mitogens.Dephosphorylation occurs at growth arrest. The protein maycontribute to the control of cell growth and proliferation throughthe selective translation of particular classes of mRNA. As istypical for genes encoding ribosomal proteins, there are multipleprocessed pseudogenes of this gene dispersed through the genome.

Titration of the RPS6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 220-249 from the human protein was used as the immunogen for this RPS6 antibody.

Aliquot the RPS6 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.