The protein encoded by this gene is a member of the S100family of proteins containing 2 EF-hand calcium-binding motifs.S100 proteins are localized in the cytoplasm and/or nucleus of awide range of cells, and involved in the regulation of a number ofcellular processes such as cell cycle progression anddifferentiation. S100 genes include at least 13 members which arelocated as a cluster on chromosome 1q21. This protein may functionin stimulation of Ca2+-induced Ca2+ release, inhibition ofmicrotubule assembly, and inhibition of protein kinase C-mediatedphosphorylation. Reduced expression of this protein has beenimplicated in cardiomyopathies.

Titration of the S100A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 45-75 from the human protein was used as the immunogen for this S100A1 antibody.

Aliquot the S100A1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.