S100 calcium-binding protein A8 is a protein that in humans is encoded by the S100A8 gene. It is also known as Calgranulin A, MRP8 and Calprotectin L1L subunit. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis.

Optimal dilution of the S100A8 antibody should be determined by the researcher.

Amino acids 2-89 of mouse MRP8/S100A8 were used as the immunogen for the S100A8 antibody.

After reconstitution, the S100A8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Calgranulin A, MRP8, Calprotectin L1L subunit