NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. [UniProt]

The stated application concentrations are suggested starting points. Titration of the SIRT6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A human recombinant protein was used as the immunogen for this SIRT6 antibody.

Store the SIRT6 antibody at -20oC.