This gene encodes a multifunctional protein that bindsubiquitin and regulates activation of the nuclear factor kappa-B(NF-kB) signaling pathway. The protein functions as ascaffolding/adaptor protein in concert with TNF receptor-associatedfactor 6 to mediate activation of NF-kB in response to upstreamsignals. Alternatively spliced transcript variants encoding eitherthe same or different isoforms have been identified for this gene.Mutations in this gene result in sporadic and familial Pagetdisease of bone.

Titration of the SQSTM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 383-409 from the human protein was used as the immunogen for this SQSTM1 antibody.

Aliquot the SQSTM1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.