Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Titration of the STAT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

This STAT3 antibody was produced from a mouse immunized with a recombinant protein from human.

Aliquot the STAT3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.