This gene encodes a type 1 transmembrane protein thatmediates Ca2+ influx after depletion of intracellular Ca2+ storesby gating of store-operated Ca2+ influx channels (SOCs). It is oneof several genes located in the imprinted gene domain of 11p15.5,an important tumor-suppressor gene region. Alterations in thisregion have been associated with the Beckwith-Wiedemann syndrome,Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung,ovarian, and breast cancer. This gene may play a role inmalignancies and disease that involve this region, as well as earlyhematopoiesis, by mediating attachment to stromal cells. This geneis oriented in a head-to-tail configuration with the ribonucleotidereductase 1 gene (RRM1), with the 3" end of this gene situated 1.6kb from the 5" end of the RRM1 gene.

Titration of the STIM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 509-538 from the human protein was used as the immunogen for this STIM1 antibody.

Aliquot the STIM1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.