Survivin, also called BIRC5, is a protein encoded by the human BIRC5 gene.It is a member of the IAP (inhibitor of apoptosis family.Survivin binds to the active form of Caspase-3 and -7, effector or executioner caspases, preventing them from continuing the apoptosis-signaling cascade. Expression is regulated by p53, a regulator of apoptosis-control genes which interacts with the Survivin gene promoter region to repress its expression at the mRNA and protein level.

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

A recombinant protein fragment from human Survivin was used as the immunogen for this antibody.

Aliquot the antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.

Baculoviral IAP repeat containing 5, BIRC5