Syndecans are a family of four transmembrane proteoglycans divided into two subfamilies based on transmembrane and cytoplasmic domain similarity: Syndecan 1/3 and 2/4.Via their covalently attached heparan sulphate chains, they bind a variety of ligands and play a role in a number of cell functions including adhesion, proliferation and migration.Syndecan 4 is highly expressed on the cell surface of epithelial cells and fibroblasts and plays an important role in tissue repair.Integrin-mediated binding of fibronectin to Syndecan-4 induces focal adhesions and formation of cytoskeletal stress fibers, facilitating wound healing.
Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.
A recombinant protein fragment from the N-terminal region of human Syndecan 4 was used as the immunogen for this antibody.
Aliquot the Syndecan 4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
SYND4, SDC4
