This gene encodes a member of the Ser/Thr protein kinasefamily and the TGFB receptor subfamily. The encoded protein is atransmembrane protein that has a protein kinase domain, forms aheterodimeric complex with another receptor protein, and bindsTGF-beta. This receptor/ligand complex phosphorylates proteins,which then enter the nucleus and regulate the transcription of asubset of genes related to cell proliferation. Mutations in thisgene have been associated with Marfan Syndrome, Loeys-Deitz AorticAneurysm Syndrome, and the development of various types of tumors.Alternatively spliced transcript variants encoding differentisoforms have been characterized.

Titration of the TGFBR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 13-40 from the human protein was used as the immunogen for this TGFBR2 antibody.

Aliquot the TGFBR2 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.