TLR8 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR8 is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X.

Titration of the TLR8 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 957-987 from the mouse protein was used as the immunogen for this TLR8 antibody.

Aliquot the TLR8 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.