The protein encoded by this gene is a member of theTNF-receptor superfamily. This protein is one of the majorreceptors for the tumor necrosis factor-alpha. This receptor canactivate NF-kappaB, mediate apoptosis, and function as a regulatorof inflammation. Antiapoptotic protein BCL2-associated athanogene 4(BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown tointeract with this receptor, and thus play regulatory roles in thesignal transduction mediated by the receptor. Germline mutations ofthe extracellular domains of this receptor were found to beassociated with the autosomal dominant periodic fever syndrome. Theimpaired receptor clearance is thought to be a mechanism of thedisease.

Titration of the TNFR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 17-43 from the human protein was used as the immunogen for this TNFR antibody.

Aliquot the TNFR antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.