This gene encodes a member of the p53 family oftranscription factors. An animal model, p63 -/- mice, has beenuseful in defining the role this protein plays in the developmentand maintenance of stratified epithelial tissues. p63 -/- mice haveseveral developmental defects which include the lack of limbs andother tissues, such as teeth and mammary glands, which develop as aresult of interactions between mesenchyme and epithelium. Mutationsin this gene are associated with ectodermal dysplasia, and cleftlip/palate syndrome 3 (EEC3); split-hand/foot malformation 4(SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULTsyndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammarysyndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Bothalternative splicing and the use of alternative promoters resultsin multiple transcript variants encoding different proteins. Manytranscripts encoding different proteins have been reported but thebiological validity and the full-length nature of these variantshave not been determined.

Titration of the TP63 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 651-680 from the human protein was used as the immunogen for this TP63 antibody.

Aliquot the TP63 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.