TPA is a tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism.

Titration of the tPA antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 371-399 from the human protein was used as the immunogen for this tPA antibody.

Aliquot the tPA antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.