The protein encoded by this gene is a member of the TNFreceptor associated factor (TRAF) protein family. TRAF proteinsassociate with, and mediate the signal transduction from, membersof the TNF receptor (TNFR) superfamily. This protein participatesin the signal transduction of CD40, a TNFR family member importantfor the activation of the immune response. This protein is found tobe a critical component of the lymphotoxin-beta receptor (LTbetaR)signaling complex, which induces NF-kappaB activation and celldeath initiated by LTbeta ligation. Epstein-Barr virus encodedlatent infection membrane protein-1 (LMP1) can interact with thisand several other members of the TRAF family, which may beessential for the oncogenic effects of LMP1. Three alternativelyspliced transcript variants encoding two distinct isoforms havebeen reported.

Titration of the TRAF3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 490-517 from the human protein was used as the immunogen for this TRAF3 antibody.

Aliquot the TRAF3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.