TNF Receptor-Associated Factor 1, also called EBI6, is a protein that in humans is encoded by the TRAF1 gene. The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. Siemienski et al.(1997) used fluorescence in situ hybridization to map the gene to 9q33-q34. Mosialos et al.(1995) found that LMP1, the EBV-transforming protein, specifically associates with LAP1 (TRAF3) or TRAF1 in B lymphoblasts. LMP1 expression redirects LAP1 and TRAF1 from scattered cytoplasmic structures to LMP1 plasma membrane patches. Both LAP1 and TRAF1 associated with the cytoplasmic domain of p80/TNFR2 in vivo.
The stated application concentrations are suggested starting amounts.Titration of the TRAF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the middle region of human TNF Receptor-Associated Factor 1 (HQSQLDRERILSLEQR) was used as the immunogen for this TRAF1 antibody.
After reconstitution, the TRAF1 antibody can be stored for up to one month at4oC.For long-term, aliquot and store at -20oC.Avoid repeated freezing and thawing.
