The protein encoded by this gene is a member of the TNFreceptor (TNFR) associated factor (TRAF) protein family. TRAFproteins associate with, and mediate the signal transduction fromvarious receptors of the TNFR superfamily. This protein and TRAF2form a heterodimeric complex, which is required forTNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. Theprotein complex formed by this protein and TRAF2 also interactswith inhibitor-of-apoptosis proteins (IAPs), and thus mediates theanti-apoptotic signals from TNF receptors. The expression of thisprotein can be induced by Epstein-Barr virus (EBV). EBV infectionmembrane protein 1 (LMP1) is found to interact with this and otherTRAF proteins; this interaction is thought to link LMP1-mediated Blymphocyte transformation to the signal transduction from TNFRfamily receptors. Three transcript variants encoding two differentisoforms have been found for this gene.

Titration of the TRAF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 55-83 from the human protein was used as the immunogen for this TRAF1 antibody.

Aliquot the TRAF1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.