Transient receptor potential cation channel subfamily M member 8, also known as the cold and menthol receptor 1 (CMR1), is a protein that in humans is encoded by the TRPM8 gene. TRPM8 is an ion channel, upon activation it allows the entry of Na+ (sodium) and Ca2+ (calcium) ions to the cell that leads to depolarization and the generation of an action potential. The signal is conducted from primary afferents (type C- and A-delta) eventually leading to the sensation of cold and cold pain. The TRPM8 protein is expressed in sensory neurons, and it is activated by cold temperatures and cooling agents, such as menthol and icilin whereas WS-12 and CPS-369 are the most selective agonist of TRPM8.

Optimal dilution of the TRPM8 antibody should be determined by the researcher.

Amino acids NTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKIK of human TRPM8 were used as the immunogen for the TRPM8 antibody.

After reconstitution, the TRPM8 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.