This gene encodes a member of the OSM9-like transientreceptor potential channel (OTRPC) subfamily in the transientreceptor potential (TRP) superfamily of ion channels. The encodedprotein is a Ca2+-permeable, nonselective cation channel that isthought to be involved in the regulation of systemic osmoticpressure. Mutations in this gene are the cause ofspondylometaphyseal and metatropic dysplasia and hereditary motorand sensory neuropathy type IIC. Multiple transcript variantsencoding different isoforms have been found for this gene.

Titration of the TRPV4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 160-189 from the human protein was used as the immunogen for this TRPV4 antibody.

Aliquot the TRPV4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.