This gene encodes Ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer"s and Down syndrome.

Titration of the Ubiquitin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 36-66 from the human protein was used as the immunogen for this Ubiquitin antibody.

Aliquot the Ubiquitin antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.