
VCP is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.
Titration of the VCP antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 726-755 from the human protein was used as the immunogen for this VCP antibody.
Aliquot the VCP antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.