Viral infection induces the interferon (IFN) response which triggers the production of an array of anti-viral proteins.Viperin (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is expressed in response to IFN-b binding to the IFN receptor, inducing the formation of the IFN-stimulated gene factor 3 complex which then binds to the Viperin promoter.It inhibits many DNA and RNA viruses through a diverse range of mechanisms and is involved in the PRR-mediated innate immune response.Viperin has been shown to be produced in response to TLR3 and TLR4 activation, but not TLR2 and TLR5.It may be involved in the TLR7 and TLR9-induced production of type I IFN by plasmacytoid dendritic cells (pDCs).

Provided assay concentrations are suggestions only, Viperin antibody titration may be required for optimal results.

A recombinant protein fragment from the N-terminal region of human Viperin was used as the immunogen for this antibody.

Aliquot the Viperin antibody and store frozen at -20oC or colder to avoid repeated freeze-thaw cycle.

Virus inhibitory protein endoplasmic reticulum associated interferon inducible, Virus inhibitory protein