Very Low Density Lipoprotein Receptor (VLDLR/VLDL receptor) is a member of the LDL receptor gene family which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDL receptor is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the VLDL Receptor antibody to be titered up or down for optimal performance.

A human recombinant partial protein from the C-terminal region was used as the immunogen for this VLDL Receptor antibody.

Store the VLDL Receptor antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).