von Willebrand Factor is a multimeric glycoprotein that is found in endothelial cells, plasma and platelets. It acts as a carrier protein for Factor VIII and promotes platelet adhesion and aggregation. vWF undergoes a variety of posttranslational modifications that influence the affinity and availability for Factor VIII, including cleavage of the propeptide and formation of N-terminal disulfide bonds. This vWF antibody helps to establish the endothelial nature of some lesions of disputed histogenesis, e.g. Kaposi�s sarcoma and cardiac myxoma. It is widely used for differentiating vascular lesions from those of other tissue differentiation within a panel of other vascular markers although not all tumors of endothelial differentiation contain this antigen.

The concentration stated for each application is a general starting point.Variations in protocols, secondaries and substrates may require the vWF antibody to be titered up or down for optimal performance.

Amino acids 845-949 were used as the immunogen for this vWF antibody.

Store the vWF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Coagulation FactorVIII, FactorVIII Related Antigen, F8VWF, von Willebrand Antigen 2, von Willebrand Disease (vWD), vWF, von Willebrand Factor antibody