The WNT gene family consists of structurally related geneswhich encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. Itencodes a protein which shows 98% amino acid identity to mouse Wnt3protein, and 84% to human WNT3A protein, another WNT gene product.The mouse studies show the requirement of Wnt3 in primary axisformation in the mouse. Studies of the gene expression suggest thatthis gene may play a key role in some cases of human breast,rectal, lung, and gastric cancer through activation of theWNT-beta-catenin-TCF signaling pathway. This gene is clustered withWNT15, another family member, in the chromosome 17q21 region.

Titration of the WNT3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 155-184 from the human protein was used as the immunogen for this WNT3 antibody.

Aliquot the WNT3 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.