The protein encoded by this gene is a chemokine receptorbelonging to the G protein-coupled receptor superfamily. The familymembers are characterized by the presence of 7 transmembranedomains and numerous conserved amino acids. This receptor is mostclosely related to RBS11 and the MIP1-alpha/RANTES receptor. Ittransduces a signal by increasing the intracellular calcium ionslevel. The viral macrophage inflammatory protein-II is anantagonist of this receptor and blocks signaling. Two alternativelyspliced transcript variants encoding the same protein have beenfound for this gene.

Titration of the XCR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 305-333 from human Lymphotactin Receptor was used as the immunogen for this XCR1 antibody.

Aliquot the XCR1 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.