The protein encoded by this gene functions together withDNA ligase IV and the DNA-dependent protein kinase in the repair ofDNA double-strand break by non-homologous end joining and thecompletion of V(D)J recombination events. The non-homologousend-joining pathway is required both for normal development and forsuppression of tumors. This gene functionally complements XR-1Chinese hamster ovary cell mutant, which is impaired in DNAdouble-strand breaks produced by ionizing radiation and restrictionenzymes. Alternative transcription initiation and alternativesplicing generates several transcript variants. [provided byRefSeq].
Titration of the XRCC4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 205-234 from the human protein was used as the immunogen for this XRCC4 antibody.
Aliquot the XRCC4 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.
