The protein encoded by this gene is the 80-kilodaltonsubunit of the Ku heterodimer protein which is also known asATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku isthe DNA-binding component of the DNA-dependent protein kinase, andit functions together with the DNA ligase IV-XRCC4 complex in therepair of DNA double-strand break by non-homologous end joining andthe completion of V(D)J recombination events.This genefunctionally complements Chinese hamster xrs-6, a mutant defectivein DNA double-strand break repair and in ability to undergo V(D)Jrecombination. A rare microsatellite polymorphism in this gene isassociated with cancer in patients of varying radiosensitivity.

Titration of the XRCC5 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

A portion of amino acids 424-450 from the human protein was used as the immunogen for this XRCC5 antibody.

Aliquot the XRCC5 antibody and store frozen at -20oC or colder.Avoid repeated freeze-thaw cycles.